Keep your cv to 2/3 pages max, no one wants to read jobs 10+ years ago
If you are writing a Profile, focus on the last 2 years and what you can offer.
If negotiating a new salary think about what the role is offering in terms of money rather than what you want/need. If the role is only worth x to a company and you want significantly more it probably isn’t the role for you.
Develop new skills related to your job, i.e. coding, creative writing courses things that could improve prospects
Avoid listing ‘ageing’ hobbies i.e. golf, wine tasting
Focus on transferable skills, be flexible about job titles and money (you are unlikely to find a job with exactly your old title).
If you have been out of work for a while be flexible with salary and package, if you are in a job you are demonstrating you are hireable.
Avoid jobs where success is directly linked to targets, these are often unachievable in a new job and put unwarranted pressure on you. Also you don’t want to find yourself back where you started 6 months down the line.
Don’t apply for jobs below your natural level, employers won’t be fooled into thinking they are getting a bargain and the competition for these jobs will probably be fiercer
Try and be flexible in where you are looking, you might find it easier to get a job in an obscure place where there is less competition. If you can relocate, albeit temporarily, or travel for a couple of years it will get you back in the job market.